Human adult tissue processed primary progenitor surrogate in vitro platform to read relevant transcriptomics, cytokine involved inflammatory pathways, Pulmonotoxicity, tumorogenicity etc
Human Vaccine Candidates Discovery and Development on Non-Animal Systems
An adoption with meaningful repercussions
The principles of Humane Experimental Technique has resulted in Rs concept Replacement Reduction and Refinement of animal tests The number of animals used for both preclinical and quality control is thought to be reduced to zero if vaccines are better characterised while allowing testings by a set of in vitro methods rather than in vivo scenarios The in vitro methods to detect safety related to potency of vaccines can employ alternative platforms like that of human derived celltissue based surrogate systems The humane technique facilitating increased control of critical stepsin production relating safety with potency international harmonisation and validation of test procedures
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