SkinIR System
Tissue used as testing platform
TRANSKIN Tissue engineered Human skin like tissue
About the Test
Transdifferentiation is a process whereby one cell type committed to and progressing along a specific developmental lineage switch into another cell type of a different lineage. Molecules found to have this Transdifferentiation ability can further be evaluated for their polypharmacology roles or for repurposing the therapeutic value
Assay endpoints:
Keratinocyte viability test
Effect on NF-Kappa B Transcription factor in Keratinocytes
Keratinocyte proliferation test
Anti-inflammatory assay
Cell cycle assay
PDE 4 inhibition measurement
Involucrin/Loricin expression
Metabolite profiling
Keratinotoxicity test/
Keratinocyte associated senescence
Keratinocyte associated senescence
Skin Penetration Test
Reference:
Avila AM, Bebenek I, Bonzo JA, Bourcier T, Davis Bruno KL, Carlson DB, Dubinion J, Elayan I, Harrouk W, Lee SL, Mendrick DL, Merrill JC, Peretz J, Place E, Saulnier M, Wange RL, Yao J, Zhao D, Brown PC. An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs). Regul Toxicol Pharmacol. 2020 Jul;114:104662. doi: 10.1016/j.yrtph.2020.104662. Epub 2020 Apr 20. PMID: 32325112.
Reviews
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