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Human surrogate in vitro systems (HuSu) are non-animal platforms for basic and applied preclinical research, clinical trials, manufacturing stages of discovery and development of drug, cosmetics, vaccine candidates. Pluripotent stem cells or primary cancer cells have the human genome background as their originating donor species, while the readouts from various assays are predictive of the human cellular system. This is a vital feature, and is an advancement over the transformed cell lines or animal species as the testing systems. Their (HuSu) phenotype, genotype and functionality can be configured, defined and quality controlled for a desired application ranging between screening chemical library stage till quality tests performed during batch wise production of the developed drug or cosmetics or vaccine for real time applications. Because these systems can be produced in large scale, reproduce the human cellular, molecular and biochemical context, are predictive of effects on human biology, and lend themselves to automated procedures (such as HTS), to existing laboratory and industrial workflows, they have begun to take on great value. The various biochemical, physiological, toxicological, and safety related variables exhibited by hits or lead candidates can be examined in detail in these systems, at the desired throughput and scale. They are as effective as the current models in practice for several purposes, and are also consistent and inexpensive to integrate. Transcell proudly offers a variety of advanced in vitro human surrogate systems/ platforms in customized configurations, including induced pluripotent cells, primary cells, and tumor tissue based for the intended testing purposes.
The following are the features and advantages of HuSu integration in to discovery, developmental stages of the specified industry:
Ethically Immuned Sources to produce human surrogate systems in the labs
Cell Based Platforms Mimicking Human physiology/milieu
Composed of human adult progenitor cells
Can be configured and customized in units to use as screens
Can be maintained in sterile conditions
Can be cryopreserved till use
Can be shipped anywhere in the world
Phenotypically responsive, Genotypically reactive, Functionally viable
Have the capability to become Human neurons in the labs
Have the capability to generate Vaccine candidate’s Neurovirulence and Cytokine storm related read outs
Requires no heavy infrastructure to integrate the systems